Nitric Oxide–Mediated Zinc Release
نویسندگان
چکیده
منابع مشابه
A tautomeric zinc sensor for ratiometric fluorescence imaging: application to nitric oxide-induced release of intracellular zinc.
Zinc is an essential metal ion for human growth and development, the disruption of cellular Zn(2+) homeostasis being implicated in several major disorders including Alzheimer's disease, diabetes, and cancer. The molecular mechanisms of Zn(2+) physiology and pathology are insufficiently understood, however, owing in part to the lack of tools for measuring changes in intracellular Zn(2+) concentr...
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The metal binding protein metallothionein (MT) is a target for nitric oxide (NO), causing release of bound zinc that affects myogenic reflex in systemic resistance vessels. Here, we investigate a role for NO-induced zinc release in pulmonary vasoregulation. We show that acute hypoxia causes reversible constriction of intraacinar arteries (<50 microm/L) in isolated perfused mouse lung (IPL). We ...
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Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism in the lung that redistributes pulmonary blood flow from areas of low oxygen tension to areas of high oxygen availability. This mechanism thus optimizes pulmonary gas exchange.1–3 Impairment of HPV can result in severe hypoxemia. However, under conditions of global alveolar hypoxia, it becomes grossly ineffective and acute pulmo...
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Many xenobiotic compounds exert their actions through the release of free radicals and related oxidants 12, bringing about unwanted biological effects 3. Indeed, oxidative events may play a significant role in tobacco toxicity from cigarette smoke. Here, we demonstrate the direct in vitro release of the free radical nitric oxide (*NO) from extracts and components of smokeless tobacco, including...
متن کاملNitric oxide release: part I. Macromolecular scaffolds.
The roles of nitric oxide (NO) in physiology and pathophysiology merit the use of NO as a therapeutic for certain biomedical applications. Unfortunately, limited NO payloads, too rapid NO release, and the lack of targeted NO delivery have hindered the clinical utility of NO gas and low molecular weight NO donor compounds. A wide-variety of NO-releasing macromolecular scaffolds has thus been dev...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2008
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.108.178962